Study results

07 Tháng Năm 20151:09 SA(Xem: 2742)
Study results
Maintenance of Stem Cell Growth
An in-vitro test was conducted on umbilical cord blood stem cells with Malus Domestica stem cell extract which is the active component of PhytoCellTec™ Malus Domestica. Umbilical cord blood stem cells (UCBSC) are the “youngest” safely available stem cells for research.

The influence of Malus Domestica stem cell extract on UCBSC artificial growth was evaluated by counting the cell number after incubation.

Results showed that Malus Domestica stem cell extract has a positive effect on UCBSC’s artificial growth thus maintaining the growth and the proliferative activity of UCBSC.

* Graph of Stem Cell Growth

Protection against UV Radiation
A second in-vitro test was conducted on umbilical cord blood stem cells with Malus Domestica stem cell extract which is the active component of PhytoCellTec™ Malus Domestica.

The protective effect against UV damage of Malus Domestica stem cell extract on UCBSC was evaluated by an MTS assay. UCBSC were incubated with different concentrations of Malus Domestica stem cell extract for 24h and were then exposed to UV radiation. The MTS assay, which measures the number of living cells and therefore the damage from UV, was performed 48h after UV radiation.

Results showed the capacity of Malus Domestica stem cell extract to protect UCBSC from UV damage even at low concentrations.

* Graph of Stem Cells against UV damage

Effect on Gene Expression in Senescent Dermal Fibroblasts
Recently a cellular model for premature senescence was established based on normal human dermal fibroblasts. After a two hours treatment with H2O2 the cells showed the typical signs of senescence. This model was used to prove the anti-senescence effect of the Malus Domestica stem cell extract. After the H2O2 treatment, the fibroblast cells were incubated with a 2% extract for 144 hours. Then gene expression was analyzed with a cDNA array system comprising 150 probes.

Results showed that Malus Domestica stem cell extract can up-regulate specific genes involved in:
  • Delay of senescence
  • Protection against oxidative stress
  • Repair of DNA
* Chart on genes involved in senescence

Anti-Wrinkle Effect on “Crow’s Feet”
The anti-wrinkle effect of PhytoCellTec™ Malus Domestica was evaluated in a study with 20 volunteers aged from 37 to 64.

An emulsion containing 2% of PhytoCellTec™ Malus Domestica was applied twice daily for 28 days to the crow’s feet. Wrinkle depth was determined by means of PRIMOS (phase-shifting rapid in vivo measurement of skin).

Results showed a significant and visible decrease in wrinkle depth for 100 % of the subjects.

* Photos of crows feet area

Apple Stem Cells
A Swiss Apple Variety with Incredible Properties Uttwiler Spätlauber is a variety of a Swiss apple that derives from a seedling planted in the middle of the 18th century. It was very famous for its excellent storability without shriveling. Today apple cultivars are selected to maximize crop yield and sweet flavor. Thus Uttwiler Spätlauber with its acid taste is now disappearing. Uttwiler Spätlauber is an endangered apple variety that was well-known for its excellent storability and thus its longevity potential. Uttwiler Spätlauber apples are rich in phytonutrients, proteins and long-living cells. This particular composition leads to incredible storability and longevity properties.

PhytoCellTec™ Malus Domestica is a liposomal preparation based on the stem cells of a rare Swiss apple.

A Revolutionary Technology to Protect Skin Stem Cells

Claims with PhytoCellTec™ Malus Domestica

  • Protects longevity of skin stem cells
  • Delays senescence of essential cells
  • Combats chronological aging
  • Preserves the youthful look and the vitality of your skin
Stem Cells and Longevity
Longevity is related to specific cells called stem cells which have a unique growth characteristic. These unspecialized (undifferentiated) cells can make identical copies of themselves as well as differentiate to become specialized cells.

Two basic types of stem cells are present in the human body:
  • Embryonic stem cells found in blastocysts can grow and differentiate into one of the more than 220 different cell types which make up the human body.
  • Adult stem cells located in some adult tissues can only differentiate into their own or related cell types. These cells act as a repair system for the body but also maintain the normal turnover of regenerative organs such as blood, skin or intestinal tissues.

Stem Cells in the Human Skin
Epidermal stem cells replenish and maintain the balance of cells within the skin tissue and regenerate tissue damages during injury. But with age, the number of skin stem cells decreases and their ability to repair the skin becomes less efficient.

Plant Stem Cells to Protect Skin Stem Cells
In contrast to human, plant cells are totipotent, meaning that every cell has the ability to regenerate new organs (leave, flower, seed…) or even the whole plant. Besides, all plant cells can dedifferentiate and become a stem cell. All stem cells, independently of their origin (plant, animal or human) contain specific epigenetic factors whose function is to maintain the self-renewal capacity of stem cells.
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